Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats

This study was conducted to investigate the effects of α-lipoic acid and coenzyme Q10 on plasma levels of lipids, asymmetric dimethylarginine, oxidative stress in fructose fed rats which provide a model of dietary-induced insulin resistance and to evaluate vascular changes developing in these rats b...

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Main Authors:	Özdoğan, Serhat, Kaman, Dilara, Şimşek, Bengü Çobanoğlu
Format:	Online
Language:	English
Published:	the Society for Free Radical Research Japan 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303477/

id	pubmed-3303477
recordtype	oai_dc
spelling	pubmed-33034772012-03-23 Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats Özdoğan, Serhat Kaman, Dilara Şimşek, Bengü Çobanoğlu Original Article This study was conducted to investigate the effects of α-lipoic acid and coenzyme Q10 on plasma levels of lipids, asymmetric dimethylarginine, oxidative stress in fructose fed rats which provide a model of dietary-induced insulin resistance and to evaluate vascular changes developing in these rats by histologically. Male Sprague Dawley rats were used in this study. The animals were divided into 4 groups. Group 1 did not receive any medication and served as a control. Group 2 received a regular diet and water ad libitum and fructose was administered as % 10 solution in drinking water. Group 3 received α-lipoic acid (100 mg/kg/day) i.p. for 5 weeks and Group 4 received coenzyme Q10 (10 mg/kg/day) i.p. for 5 weeks. For determination of plasma asymmetric dimethylarginine, glutathione and malondialdehyde levels, high-performance liquid chromatography system was used. Homeostatic model assessment as a measure of insulin resistance was calculated. Lipid profile measurements were determined using enzymatic assay on an Auto analyzer. The high fructose diet was significantly associated with an increase in levels of plasma LDL, VLDL and total cholesterol and decrease in level of HDL cholesterol. Plasma asymmetric dimethylarginine, malondialdehyde and glutathione levels were also increase in these rats. α-lipoic acid or coenzyme Q10 supplementation was found to have some positive effect on these parameters. These findings were also demonstrated by morphological observation of the aorta. We demonstrated that administration of α-lipoic acid and coenzyme Q10 notably suppresses oxidative and nitrative stress, hyperinsulinemia, insulin resistance developing in fructose fed rats, a model of metabolic syndrome (MS). These positive effects of α-lipoic acid or coenzyme Q10 can be attributed to its antioxidant activity. the Society for Free Radical Research Japan 2012-03 2011-09-03 /pmc/articles/PMC3303477/ /pubmed/22448096 http://dx.doi.org/10.3164/jcbn.11-47 Text en Copyright © 2012 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Özdoğan, Serhat Kaman, Dilara Şimşek, Bengü Çobanoğlu
spellingShingle	Özdoğan, Serhat Kaman, Dilara Şimşek, Bengü Çobanoğlu Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats
author_facet	Özdoğan, Serhat Kaman, Dilara Şimşek, Bengü Çobanoğlu
author_sort	Özdoğan, Serhat
title	Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats
title_short	Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats
title_full	Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats
title_fullStr	Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats
title_full_unstemmed	Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats
title_sort	effects of coenzyme q10 and α-lipoic acid supplementation in fructose fed rats
description	This study was conducted to investigate the effects of α-lipoic acid and coenzyme Q10 on plasma levels of lipids, asymmetric dimethylarginine, oxidative stress in fructose fed rats which provide a model of dietary-induced insulin resistance and to evaluate vascular changes developing in these rats by histologically. Male Sprague Dawley rats were used in this study. The animals were divided into 4 groups. Group 1 did not receive any medication and served as a control. Group 2 received a regular diet and water ad libitum and fructose was administered as % 10 solution in drinking water. Group 3 received α-lipoic acid (100 mg/kg/day) i.p. for 5 weeks and Group 4 received coenzyme Q10 (10 mg/kg/day) i.p. for 5 weeks. For determination of plasma asymmetric dimethylarginine, glutathione and malondialdehyde levels, high-performance liquid chromatography system was used. Homeostatic model assessment as a measure of insulin resistance was calculated. Lipid profile measurements were determined using enzymatic assay on an Auto analyzer. The high fructose diet was significantly associated with an increase in levels of plasma LDL, VLDL and total cholesterol and decrease in level of HDL cholesterol. Plasma asymmetric dimethylarginine, malondialdehyde and glutathione levels were also increase in these rats. α-lipoic acid or coenzyme Q10 supplementation was found to have some positive effect on these parameters. These findings were also demonstrated by morphological observation of the aorta. We demonstrated that administration of α-lipoic acid and coenzyme Q10 notably suppresses oxidative and nitrative stress, hyperinsulinemia, insulin resistance developing in fructose fed rats, a model of metabolic syndrome (MS). These positive effects of α-lipoic acid or coenzyme Q10 can be attributed to its antioxidant activity.
publisher	the Society for Free Radical Research Japan
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303477/
_version_	1611513834490560512

Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats

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