Regular Patterns for Proteome-Wide Distribution of Protein Abundance across Species
A proteome of the bio-entity, including cell, tissue, organ, and organism, consists of proteins of diverse abundance. The principle that determines the abundance of different proteins in a proteome is of fundamental significance for an understanding of the building blocks of the bio-entity. Here, we...
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| Format: | Online |
| Language: | English |
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Public Library of Science
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302874/ |
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pubmed-3302874 |
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pubmed-33028742012-03-16 Regular Patterns for Proteome-Wide Distribution of Protein Abundance across Species Zhong, Fan Yang, Dong Hao, Yunwei Lin, Chengzhao Jiang, Ying Ying, Wantao Wu, Songfeng Zhu, Yunping Liu, Siqi Yang, Pengyuan Qian, Xiaohong He, Fuchu Research Article A proteome of the bio-entity, including cell, tissue, organ, and organism, consists of proteins of diverse abundance. The principle that determines the abundance of different proteins in a proteome is of fundamental significance for an understanding of the building blocks of the bio-entity. Here, we report three regular patterns in the proteome-wide distribution of protein abundance across species such as human, mouse, fly, worm, yeast, and bacteria: in most cases, protein abundance is positively correlated with the protein's origination time or sequence conservation during evolution; it is negatively correlated with the protein's domain number and positively correlated with domain coverage in protein structure, and the correlations became stronger during the course of evolution; protein abundance can be further stratified by the function of the protein, whereby proteins that act on material conversion and transportation (mass category) are more abundant than those that act on information modulation (information category). Thus, protein abundance is intrinsically related to the protein's inherent characters of evolution, structure, and function. Public Library of Science 2012-03-09 /pmc/articles/PMC3302874/ /pubmed/22427835 http://dx.doi.org/10.1371/journal.pone.0032423 Text en Zhong et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zhong, Fan Yang, Dong Hao, Yunwei Lin, Chengzhao Jiang, Ying Ying, Wantao Wu, Songfeng Zhu, Yunping Liu, Siqi Yang, Pengyuan Qian, Xiaohong He, Fuchu |
| spellingShingle |
Zhong, Fan Yang, Dong Hao, Yunwei Lin, Chengzhao Jiang, Ying Ying, Wantao Wu, Songfeng Zhu, Yunping Liu, Siqi Yang, Pengyuan Qian, Xiaohong He, Fuchu Regular Patterns for Proteome-Wide Distribution of Protein Abundance across Species |
| author_facet |
Zhong, Fan Yang, Dong Hao, Yunwei Lin, Chengzhao Jiang, Ying Ying, Wantao Wu, Songfeng Zhu, Yunping Liu, Siqi Yang, Pengyuan Qian, Xiaohong He, Fuchu |
| author_sort |
Zhong, Fan |
| title |
Regular Patterns for Proteome-Wide Distribution of Protein Abundance across Species |
| title_short |
Regular Patterns for Proteome-Wide Distribution of Protein Abundance across Species |
| title_full |
Regular Patterns for Proteome-Wide Distribution of Protein Abundance across Species |
| title_fullStr |
Regular Patterns for Proteome-Wide Distribution of Protein Abundance across Species |
| title_full_unstemmed |
Regular Patterns for Proteome-Wide Distribution of Protein Abundance across Species |
| title_sort |
regular patterns for proteome-wide distribution of protein abundance across species |
| description |
A proteome of the bio-entity, including cell, tissue, organ, and organism, consists of proteins of diverse abundance. The principle that determines the abundance of different proteins in a proteome is of fundamental significance for an understanding of the building blocks of the bio-entity. Here, we report three regular patterns in the proteome-wide distribution of protein abundance across species such as human, mouse, fly, worm, yeast, and bacteria: in most cases, protein abundance is positively correlated with the protein's origination time or sequence conservation during evolution; it is negatively correlated with the protein's domain number and positively correlated with domain coverage in protein structure, and the correlations became stronger during the course of evolution; protein abundance can be further stratified by the function of the protein, whereby proteins that act on material conversion and transportation (mass category) are more abundant than those that act on information modulation (information category). Thus, protein abundance is intrinsically related to the protein's inherent characters of evolution, structure, and function. |
| publisher |
Public Library of Science |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302874/ |
| _version_ |
1611513725700800512 |