A Dominant Negative ERβ Splice Variant Determines the Effectiveness of Early or Late Estrogen Therapy after Ovariectomy in Rats

A Dominant Negative ERβ Splice Variant Determines the Effectiveness of Early or Late Estrogen Therapy after Ovariectomy in Rats

The molecular mechanisms for the discrepancy in outcome of initiating estrogen therapy (ET) around peri-menopause or several years after menopause in women are unknown. We hypothesize that the level of expression of a dominant negative estrogen receptor (ER) β variant, ERβ2, may be a key factor dete...

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Bibliographic Details
Main Authors: Wang, Jun Ming, Hou, Xu, Adeosun, Samuel, Hill, Rosanne, Henry, Sherry, Paul, Ian, Irwin, Ronald W., Ou, Xiao-Ming, Bigler, Steven, Stockmeier, Craig, Brinton, Roberta Diaz, Gomez-Sanchez, Elise
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302771/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302771/

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