Recurrent Pregnancy Loss and Thrombophilia

Emerging data seem to be available also on the role of active thromboprophylaxis with heparin and pregnancy outcome. In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss...

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Main Authors:	D’Uva, Maristella, Micco, Pierpaolo Di, Strina, Ida, Placido, Giuseppe De
Format:	Online
Language:	English
Published:	Elmer Press 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299170/

id	pubmed-3299170
recordtype	oai_dc
spelling	pubmed-32991702012-03-28 Recurrent Pregnancy Loss and Thrombophilia D’Uva, Maristella Micco, Pierpaolo Di Strina, Ida Placido, Giuseppe De Review Emerging data seem to be available also on the role of active thromboprophylaxis with heparin and pregnancy outcome. In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). First studies which focused on the association between thrombophilia and RPL underlined the role of reduced clotting inhibitors and RPL, and subsequent studies underlined a pathogenetic role of gene variant associated to hypercoagulable state in the occurrence of RPL. On the other hand, acquired thrombophilic abnormalities as antiphipsholipid syndrome are a well known cause of RPL and should be considered for a screening. These data are relevant because recent studies suggested a role of an extensive thromprophilaxis in women with RPL that should be addressed only in case of known thrombophilia and high risk of venous thromboembolism. Elmer Press 2010-02 2010-02-26 /pmc/articles/PMC3299170/ /pubmed/22457696 http://dx.doi.org/10.4021/jocmr2010.02.260w Text en Copyright 2010, D’Uva et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	D’Uva, Maristella Micco, Pierpaolo Di Strina, Ida Placido, Giuseppe De
spellingShingle	D’Uva, Maristella Micco, Pierpaolo Di Strina, Ida Placido, Giuseppe De Recurrent Pregnancy Loss and Thrombophilia
author_facet	D’Uva, Maristella Micco, Pierpaolo Di Strina, Ida Placido, Giuseppe De
author_sort	D’Uva, Maristella
title	Recurrent Pregnancy Loss and Thrombophilia
title_short	Recurrent Pregnancy Loss and Thrombophilia
title_full	Recurrent Pregnancy Loss and Thrombophilia
title_fullStr	Recurrent Pregnancy Loss and Thrombophilia
title_full_unstemmed	Recurrent Pregnancy Loss and Thrombophilia
title_sort	recurrent pregnancy loss and thrombophilia
description	Emerging data seem to be available also on the role of active thromboprophylaxis with heparin and pregnancy outcome. In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). First studies which focused on the association between thrombophilia and RPL underlined the role of reduced clotting inhibitors and RPL, and subsequent studies underlined a pathogenetic role of gene variant associated to hypercoagulable state in the occurrence of RPL. On the other hand, acquired thrombophilic abnormalities as antiphipsholipid syndrome are a well known cause of RPL and should be considered for a screening. These data are relevant because recent studies suggested a role of an extensive thromprophilaxis in women with RPL that should be addressed only in case of known thrombophilia and high risk of venous thromboembolism.
publisher	Elmer Press
publishDate	2010
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299170/
_version_	1611512129280540672

Recurrent Pregnancy Loss and Thrombophilia

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