Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture

Introduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated the hypothesis of a bidirectional link betwe...

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Main Authors:	Fisher, Alexander, Srikusalanukul, Wichat, Davis, Michael, Smith, Paul
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296446/

id	pubmed-3296446
recordtype	oai_dc
spelling	pubmed-32964462012-04-19 Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture Fisher, Alexander Srikusalanukul, Wichat Davis, Michael Smith, Paul Research Article Introduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated the hypothesis of a bidirectional link between adipokines and osteocalcin. Materials and Methods. In a cross-sectional study of 294 older patients with osteoporotic hip fracture, we estimated serum concentrations of leptin, adiponectin, resistin, osteocalcin, parameters of mineral metabolism, and renal function. Results. After adjustment for multiple potential confounders, serum osteocalcin concentration was inversely associated with resistin and positively with leptin, leptin/resistin ratio, and adiponectin/resistin ratio. In multivariate regression models, osteocalcin was an independent predictor of serum leptin, resistin, leptin/resistin, and adiponectin/resistin ratios. Conclusions. Our data support the bidirectional regulation between osteocalcin and adipokines, but contrary to the genetically modified animal models, in older subjects with osteoporotic hip fracture, serum osteocalcin is positively associated with leptin and inversely with resistin. Hindawi Publishing Corporation 2012 2012-02-22 /pmc/articles/PMC3296446/ /pubmed/22518129 http://dx.doi.org/10.1155/2012/684323 Text en Copyright © 2012 Alexander Fisher et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Fisher, Alexander Srikusalanukul, Wichat Davis, Michael Smith, Paul
spellingShingle	Fisher, Alexander Srikusalanukul, Wichat Davis, Michael Smith, Paul Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture
author_facet	Fisher, Alexander Srikusalanukul, Wichat Davis, Michael Smith, Paul
author_sort	Fisher, Alexander
title	Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture
title_short	Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture
title_full	Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture
title_fullStr	Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture
title_full_unstemmed	Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture
title_sort	interactions between serum adipokines and osteocalcin in older patients with hip fracture
description	Introduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated the hypothesis of a bidirectional link between adipokines and osteocalcin. Materials and Methods. In a cross-sectional study of 294 older patients with osteoporotic hip fracture, we estimated serum concentrations of leptin, adiponectin, resistin, osteocalcin, parameters of mineral metabolism, and renal function. Results. After adjustment for multiple potential confounders, serum osteocalcin concentration was inversely associated with resistin and positively with leptin, leptin/resistin ratio, and adiponectin/resistin ratio. In multivariate regression models, osteocalcin was an independent predictor of serum leptin, resistin, leptin/resistin, and adiponectin/resistin ratios. Conclusions. Our data support the bidirectional regulation between osteocalcin and adipokines, but contrary to the genetically modified animal models, in older subjects with osteoporotic hip fracture, serum osteocalcin is positively associated with leptin and inversely with resistin.
publisher	Hindawi Publishing Corporation
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296446/
_version_	1611511244609552384

Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture

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