Bistability in feedback circuits as a byproduct of evolution of evolvability

Simulations of the evolution of simple gene regulatory networks reveal that fluctuating environmental selection can lead to the emergence of bistability under certain conditions where fluctuation and mutational rates are in tune.

Bibliographic Details
Main Authors: Kuwahara, Hiroyuki, Soyer, Orkun S
Format: Online
Language:English
Published: Nature Publishing Group 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296359/