Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis

Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of co...

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Main Authors:	Kim, Yong-Nyun, Koo, Kyung Hee, Sung, Jee Young, Yun, Un-Jung, Kim, Hyeryeong
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296207/

id	pubmed-3296207
recordtype	oai_dc
spelling	pubmed-32962072012-04-13 Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong Review Article Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts. Hindawi Publishing Corporation 2012 2012-02-23 /pmc/articles/PMC3296207/ /pubmed/22505926 http://dx.doi.org/10.1155/2012/306879 Text en Copyright © 2012 Yong-Nyun Kim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong
spellingShingle	Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
author_facet	Kim, Yong-Nyun Koo, Kyung Hee Sung, Jee Young Yun, Un-Jung Kim, Hyeryeong
author_sort	Kim, Yong-Nyun
title	Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_short	Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_full	Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_fullStr	Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_full_unstemmed	Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis
title_sort	anoikis resistance: an essential prerequisite for tumor metastasis
description	Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant target organs. As a barrier to metastasis, cells normally undergo an apoptotic process known as “anoikis,” a form of cell death due to loss of contact with the extracellular matrix or neighboring cells. Cancer cells acquire anoikis resistance to survive after detachment from the primary sites and travel through the circulatory and lymphatic systems to disseminate throughout the body. Because recent technological advances enable us to detect rare circulating tumor cells, which are anoikis resistant, currently, anoikis resistance becomes a hot topic in cancer research. Detailed molecular and functional analyses of anoikis resistant cells may provide insight into the biology of cancer metastasis and identify novel therapeutic targets for prevention of cancer dissemination. This paper comprehensively describes recent investigations of the molecular and cellular mechanisms underlying anoikis and anoikis resistance in relation to intrinsic and extrinsic death signaling, epithelial-mesenchymal transition, growth factor receptors, energy metabolism, reactive oxygen species, membrane microdomains, and lipid rafts.
publisher	Hindawi Publishing Corporation
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296207/
_version_	1611511131837300736

Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis

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