Selection of recombinant MVA by rescue of the essential D4R gene

Modified vaccinia virus Ankara (MVA) has become a promising vaccine vector due to its immunogenicity and its proven safety in humans. As a general approach for stringent and rapid selection of recombinant MVA, we assessed marker rescue of the essential viral D4R gene in an engineered deletion mutant...

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Bibliographic Details
Main Authors: Ricci, Patricia S, Schäfer, Birgit, Kreil, Thomas R, Falkner, Falko G, Holzer, Georg W
Format: Online
Language:English
Published: BioMed Central 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293099/