Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma
PTEN is an essential tumor suppressor that antagonizes Akt/PKB signaling. The zebrafish genome encodes two Pten genes, ptena and ptenb. Here, we report that zebrafish mutants that retain a single wild-type copy of ptena or ptenb (ptena+/−ptenb−/− or ptena−/−ptenb+/−) are viable and fertile. ptena+/−...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Company of Biologists Limited
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291645/ |