Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area

Background. To describe the clinical characteristics of the patients who suffered from relapse after conventional irradiation for nasopharyngeal carcinoma (NPC). Methods. Three hundred and fifty-one consecutive patients with first-time recurrent NPC between January 1999 and July 2005 were included....

Full description

Bibliographic Details
Main Authors:	Li, Jia-Xin, Lu, Tai-Xiang, Huang, Ying, Han, Fei
Format:	Online
Language:	English
Published:	The Scientific World Journal 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289855/

id	pubmed-3289855
recordtype	oai_dc
spelling	pubmed-32898552012-03-23 Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area Li, Jia-Xin Lu, Tai-Xiang Huang, Ying Han, Fei Clinical Study Background. To describe the clinical characteristics of the patients who suffered from relapse after conventional irradiation for nasopharyngeal carcinoma (NPC). Methods. Three hundred and fifty-one consecutive patients with first-time recurrent NPC between January 1999 and July 2005 were included. The patients' clinical data were reviewed, including recurrent interval time, symptoms, signs, imaging characteristics, pathologic features, and restaging. Results. The median interval of relapse was 26.0 months. The most common symptoms in symptomatic patients were nasal bloody discharge (37.9%) and headache (31.1%). Local recurrence alone accounted for 73.5%. Most patients were restaged as stage III (23.1%) and stage IV (51.1%). Subgroup analysis suggested a significantly higher proportion of the long-latent relapses originated from early primary. A series of postreirradiation complications were more frequent in patients with longer latency at reception. Conclusions. Most recurrent nasopharyngeal carcinoma is advanced disease. Patients with different recurrent interval time show different nature behavior. The Scientific World Journal 2012-02-01 /pmc/articles/PMC3289855/ /pubmed/22448138 http://dx.doi.org/10.1100/2012/719754 Text en Copyright © 2012 Jia-Xin Li et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Li, Jia-Xin Lu, Tai-Xiang Huang, Ying Han, Fei
spellingShingle	Li, Jia-Xin Lu, Tai-Xiang Huang, Ying Han, Fei Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area
author_facet	Li, Jia-Xin Lu, Tai-Xiang Huang, Ying Han, Fei
author_sort	Li, Jia-Xin
title	Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area
title_short	Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area
title_full	Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area
title_fullStr	Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area
title_full_unstemmed	Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area
title_sort	clinical characteristics of recurrent nasopharyngeal carcinoma in high-incidence area
description	Background. To describe the clinical characteristics of the patients who suffered from relapse after conventional irradiation for nasopharyngeal carcinoma (NPC). Methods. Three hundred and fifty-one consecutive patients with first-time recurrent NPC between January 1999 and July 2005 were included. The patients' clinical data were reviewed, including recurrent interval time, symptoms, signs, imaging characteristics, pathologic features, and restaging. Results. The median interval of relapse was 26.0 months. The most common symptoms in symptomatic patients were nasal bloody discharge (37.9%) and headache (31.1%). Local recurrence alone accounted for 73.5%. Most patients were restaged as stage III (23.1%) and stage IV (51.1%). Subgroup analysis suggested a significantly higher proportion of the long-latent relapses originated from early primary. A series of postreirradiation complications were more frequent in patients with longer latency at reception. Conclusions. Most recurrent nasopharyngeal carcinoma is advanced disease. Patients with different recurrent interval time show different nature behavior.
publisher	The Scientific World Journal
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289855/
_version_	1611509134302117888

Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area

Similar Items