Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage

Zika virus (ZIKV) is a mosquito-transmitted flavivirus found in both Africa and Asia. Human infection with the virus may result in a febrile illness similar to dengue fever and many other tropical infections found in these regions. Previously, little was known about the genetic relationships between...

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Main Authors:	Haddow, Andrew D., Schuh, Amy J., Yasuda, Chadwick Y., Kasper, Matthew R., Heang, Vireak, Huy, Rekol, Guzman, Hilda, Tesh, Robert B., Weaver, Scott C.
Format:	Online
Language:	English
Published:	Public Library of Science 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289602/

id	pubmed-3289602
recordtype	oai_dc
spelling	pubmed-32896022012-03-02 Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage Haddow, Andrew D. Schuh, Amy J. Yasuda, Chadwick Y. Kasper, Matthew R. Heang, Vireak Huy, Rekol Guzman, Hilda Tesh, Robert B. Weaver, Scott C. Research Article Zika virus (ZIKV) is a mosquito-transmitted flavivirus found in both Africa and Asia. Human infection with the virus may result in a febrile illness similar to dengue fever and many other tropical infections found in these regions. Previously, little was known about the genetic relationships between ZIKV strains collected in Africa and those collected in Asia. In addition, the geographic origins of the strains responsible for the recent outbreak of human disease on Yap Island, Federated States of Micronesia, and a human case of ZIKV infection in Cambodia were unknown. Our results indicate that there are two geographically distinct lineages of ZIKV (African and Asian). The virus has circulated in Southeast Asia for at least the past 50 years, whereupon it was introduced to Yap Island resulting in an epidemic of human disease in 2007, and in 2010 was the cause of a pediatric case of ZIKV infection in Cambodia. This study also highlights the danger of ZIKV introduction into new areas and the potential for future epidemics of human disease. Public Library of Science 2012-02-28 /pmc/articles/PMC3289602/ /pubmed/22389730 http://dx.doi.org/10.1371/journal.pntd.0001477 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Haddow, Andrew D. Schuh, Amy J. Yasuda, Chadwick Y. Kasper, Matthew R. Heang, Vireak Huy, Rekol Guzman, Hilda Tesh, Robert B. Weaver, Scott C.
spellingShingle	Haddow, Andrew D. Schuh, Amy J. Yasuda, Chadwick Y. Kasper, Matthew R. Heang, Vireak Huy, Rekol Guzman, Hilda Tesh, Robert B. Weaver, Scott C. Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage
author_facet	Haddow, Andrew D. Schuh, Amy J. Yasuda, Chadwick Y. Kasper, Matthew R. Heang, Vireak Huy, Rekol Guzman, Hilda Tesh, Robert B. Weaver, Scott C.
author_sort	Haddow, Andrew D.
title	Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage
title_short	Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage
title_full	Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage
title_fullStr	Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage
title_full_unstemmed	Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage
title_sort	genetic characterization of zika virus strains: geographic expansion of the asian lineage
description	Zika virus (ZIKV) is a mosquito-transmitted flavivirus found in both Africa and Asia. Human infection with the virus may result in a febrile illness similar to dengue fever and many other tropical infections found in these regions. Previously, little was known about the genetic relationships between ZIKV strains collected in Africa and those collected in Asia. In addition, the geographic origins of the strains responsible for the recent outbreak of human disease on Yap Island, Federated States of Micronesia, and a human case of ZIKV infection in Cambodia were unknown. Our results indicate that there are two geographically distinct lineages of ZIKV (African and Asian). The virus has circulated in Southeast Asia for at least the past 50 years, whereupon it was introduced to Yap Island resulting in an epidemic of human disease in 2007, and in 2010 was the cause of a pediatric case of ZIKV infection in Cambodia. This study also highlights the danger of ZIKV introduction into new areas and the potential for future epidemics of human disease.
publisher	Public Library of Science
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289602/
_version_	1611509061360025600

Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage

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