Evidence for dynamics in proteins as a mechanism for ligand dissociation
Signal transduction, regulatory processes, and pharmaceutical responses are highly dependent upon ligand residence times. Gaining insight into how physical factors influence residence times, or koff, should enhance our ability to manipulate biological interactions. We report experiments that yield s...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288659/ |