Power of association tests in the presence of multiple causal variants

Power of association tests in the presence of multiple causal variants

We show that the statistical power of a single single-nucleotide polymorphism (SNP) score test for genetic association reflects the cumulative effect of all causal SNPs that are correlated with the test SNP. Statistical significance of a score test can sometimes be explained by the collective effect...

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Bibliographic Details
Main Authors:	Di, Yanming, Mi, Gu, Sun, Luna, Dong, Rongrong, Zhu, Hong, Peng, Lili
Format:	Online
Language:	English
Published:	BioMed Central 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287902/

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