Methods for detecting associations between phenotype and aggregations of rare variants

Although genome-wide association studies have uncovered variants associated with more than 150 traits, the percentage of phenotypic variation explained by these associations remains small. This has led to the search for the dark matter that explains this missing genetic component of heritability. On...

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Bibliographic Details
Main Authors: Yang, Fan, Kang, Chul Joo, Marjoram, Paul
Format: Online
Language:English
Published: BioMed Central 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287889/