Helicobacter pylori Seropositivity and Risk of Lung Cancer
Lung cancer is the leading cause of cancer mortality worldwide. Helicobacter pylori (H. pylori) is a risk factor for distal stomach cancer, and a few small studies have suggested that H. pylori may be a potential risk factor for lung cancer. To test this hypothesis, we conducted a study of 350 lung...
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| Format: | Online |
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Public Library of Science
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286451/ |
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pubmed-3286451 |
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pubmed-32864512012-03-01 Helicobacter pylori Seropositivity and Risk of Lung Cancer Koshiol, Jill Flores, Roberto Lam, Tram K. Taylor, Philip R. Weinstein, Stephanie J. Virtamo, Jarmo Albanes, Demetrius Perez-Perez, Guillermo Caporaso, Neil E. Blaser, Martin J. Research Article Lung cancer is the leading cause of cancer mortality worldwide. Helicobacter pylori (H. pylori) is a risk factor for distal stomach cancer, and a few small studies have suggested that H. pylori may be a potential risk factor for lung cancer. To test this hypothesis, we conducted a study of 350 lung adenocarcinoma cases, 350 squamous cell carcinoma cases, and 700 controls nested within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) cohort of male Finnish smokers. Controls were one-to-one matched by age and date of baseline serum draw. Using enzyme-linked immunosorbent assays to detect immunoglobulin G antibodies against H. pylori whole-cell and cytotoxin-associated gene (CagA) antigens, we calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between H. pylori seropositivity and lung cancer risk using conditional logistic regression. H. pylori seropositivity was detected in 79.7% of cases and 78.5% of controls. After adjusting for pack-years and cigarettes smoked per day, H. pylori seropositivity was not associated with either adenocarcinoma (OR: 1.1, 95% CI: 0.75–1.6) or squamous cell carcinoma (OR: 1.1, 95% CI: 0.77–1.7). Results were similar for CagA-negative and CagA-positive H. pylori seropositivity. Despite earlier small studies suggesting that H. pylori may contribute to lung carcinogenesis, H. pylori seropositivity does not appear to be associated with lung cancer. Public Library of Science 2012-02-24 /pmc/articles/PMC3286451/ /pubmed/22384154 http://dx.doi.org/10.1371/journal.pone.0032106 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Koshiol, Jill Flores, Roberto Lam, Tram K. Taylor, Philip R. Weinstein, Stephanie J. Virtamo, Jarmo Albanes, Demetrius Perez-Perez, Guillermo Caporaso, Neil E. Blaser, Martin J. |
| spellingShingle |
Koshiol, Jill Flores, Roberto Lam, Tram K. Taylor, Philip R. Weinstein, Stephanie J. Virtamo, Jarmo Albanes, Demetrius Perez-Perez, Guillermo Caporaso, Neil E. Blaser, Martin J. Helicobacter pylori Seropositivity and Risk of Lung Cancer |
| author_facet |
Koshiol, Jill Flores, Roberto Lam, Tram K. Taylor, Philip R. Weinstein, Stephanie J. Virtamo, Jarmo Albanes, Demetrius Perez-Perez, Guillermo Caporaso, Neil E. Blaser, Martin J. |
| author_sort |
Koshiol, Jill |
| title |
Helicobacter pylori Seropositivity and Risk of Lung Cancer |
| title_short |
Helicobacter pylori Seropositivity and Risk of Lung Cancer |
| title_full |
Helicobacter pylori Seropositivity and Risk of Lung Cancer |
| title_fullStr |
Helicobacter pylori Seropositivity and Risk of Lung Cancer |
| title_full_unstemmed |
Helicobacter pylori Seropositivity and Risk of Lung Cancer |
| title_sort |
helicobacter pylori seropositivity and risk of lung cancer |
| description |
Lung cancer is the leading cause of cancer mortality worldwide. Helicobacter pylori (H. pylori) is a risk factor for distal stomach cancer, and a few small studies have suggested that H. pylori may be a potential risk factor for lung cancer. To test this hypothesis, we conducted a study of 350 lung adenocarcinoma cases, 350 squamous cell carcinoma cases, and 700 controls nested within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) cohort of male Finnish smokers. Controls were one-to-one matched by age and date of baseline serum draw. Using enzyme-linked immunosorbent assays to detect immunoglobulin G antibodies against H. pylori whole-cell and cytotoxin-associated gene (CagA) antigens, we calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between H. pylori seropositivity and lung cancer risk using conditional logistic regression. H. pylori seropositivity was detected in 79.7% of cases and 78.5% of controls. After adjusting for pack-years and cigarettes smoked per day, H. pylori seropositivity was not associated with either adenocarcinoma (OR: 1.1, 95% CI: 0.75–1.6) or squamous cell carcinoma (OR: 1.1, 95% CI: 0.77–1.7). Results were similar for CagA-negative and CagA-positive H. pylori seropositivity. Despite earlier small studies suggesting that H. pylori may contribute to lung carcinogenesis, H. pylori seropositivity does not appear to be associated with lung cancer. |
| publisher |
Public Library of Science |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286451/ |
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1611508235023417344 |