FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization

FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization

Genetic studies revealed that the ablation of insulin/IGF-1 signaling in the pancreas causes diabetes. FoxO1 is a downstream transcription factor of insulin/IGF-1 signaling. We previously reported that FoxO1 haploinsufficiency restored β cell mass and rescued diabetes in IRS2 knockout mice. However,...

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Bibliographic Details
Main Authors: Kikuchi, Osamu, Kobayashi, Masaki, Amano, Kosuke, Sasaki, Tsutomu, Kitazumi, Tomoya, Kim, Hye-Jin, Lee, Yong-Soo, Yokota-Hashimoto, Hiromi, Kitamura, Yukari-Ido, Kitamura, Tadahiro
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285669/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285669/

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