Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

Association of a Functional Variant in the Wnt Co-Receptor LRP6 with Early Onset Ileal Crohn's Disease

Ileal Crohn's Disease (CD), a chronic small intestinal inflammatory disorder, is characterized by reduced levels of the antimicrobial peptides DEFA5 (HD-5) and DEFA6 (HD-6). Both of these α-defensins are exclusively produced in Paneth cells (PCs) at small intestinal crypt bases. Different ileal...

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Bibliographic Details
Main Authors: Koslowski, Maureen J., Teltschik, Zora, Beisner, Julia, Schaeffeler, Elke, Wang, Guoxing, Kübler, Irmgard, Gersemann, Michael, Cooney, Rachel, Jewell, Derek, Reinisch, Walter, Vermeire, Séverine, Rutgeerts, Paul, Schwab, Matthias, Stange, Eduard F., Wehkamp, Jan
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285585/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285585/

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