Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans

Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans

Mutations in the DNA/RNA binding proteins TDP-43 and FUS are associated with Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Intracellular accumulations of wild type TDP-43 and FUS are observed in a growing number of late-onset diseases suggesting that TDP-43 and FUS proteinopat...

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Bibliographic Details
Main Authors: Vaccaro, Alexandra, Tauffenberger, Arnaud, Aggad, Dina, Rouleau, Guy, Drapeau, Pierre, Parker, J. Alex
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283630/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283630/

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