Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias

Robert Clarke and colleagues conduct a meta-analysis of unpublished datasets to examine the causal relationship between elevation of homocysteine levels in the blood and the risk of coronary heart disease. Their data suggest that an increase in homocysteine levels is not likely to result in an incre...

Full description

Bibliographic Details
Main Authors: Clarke, Robert, Bennett, Derrick A., Parish, Sarah, Verhoef, Petra, Dötsch-Klerk, Mariska, Lathrop, Mark, Xu, Peng, Nordestgaard, Børge G., Holm, Hilma, Hopewell, Jemma C., Saleheen, Danish, Tanaka, Toshihiro, Anand, Sonia S., Chambers, John C., Kleber, Marcus E., Ouwehand, Willem H., Yamada, Yoshiji, Elbers, Clara, Peters, Bas, Stewart, Alexandre F. R., Reilly, Muredach M., Thorand, Barbara, Yusuf, Salim, Engert, James C., Assimes, Themistocles L., Kooner, Jaspal, Danesh, John, Watkins, Hugh, Samani, Nilesh J., Collins, Rory, Peto, Richard
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283559/