Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides
There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency and other characteristics of the CR produced by various radionuclides would help in accessing the feasibility of proposed applications and guide the choi...
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| Format: | Online |
| Language: | English |
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Public Library of Science
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282695/ |
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pubmed-3282695 |
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pubmed-32826952012-02-23 Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides Beattie, Bradley J. Thorek, Daniel L. J. Schmidtlein, Charles R. Pentlow, Keith S. Humm, John L. Hielscher, Andreas H. Research Article There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency and other characteristics of the CR produced by various radionuclides would help in accessing the feasibility of proposed applications and guide the choice of radionuclides. To generate this information we developed models of CR production efficiency based on the Frank-Tamm equation and models of CR distribution based on Monte-Carlo simulations of photon and β particle transport. All models were validated against direct measurements using multiple radionuclides and then applied to a number of radionuclides commonly used in biomedical applications. We show that two radionuclides, Ac-225 and In-111, which have been reported to produce CR in water, do not in fact produce CR directly. We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use. Public Library of Science 2012-02-20 /pmc/articles/PMC3282695/ /pubmed/22363636 http://dx.doi.org/10.1371/journal.pone.0031402 Text en Beattie et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Beattie, Bradley J. Thorek, Daniel L. J. Schmidtlein, Charles R. Pentlow, Keith S. Humm, John L. Hielscher, Andreas H. |
| spellingShingle |
Beattie, Bradley J. Thorek, Daniel L. J. Schmidtlein, Charles R. Pentlow, Keith S. Humm, John L. Hielscher, Andreas H. Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides |
| author_facet |
Beattie, Bradley J. Thorek, Daniel L. J. Schmidtlein, Charles R. Pentlow, Keith S. Humm, John L. Hielscher, Andreas H. |
| author_sort |
Beattie, Bradley J. |
| title |
Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides |
| title_short |
Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides |
| title_full |
Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides |
| title_fullStr |
Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides |
| title_full_unstemmed |
Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides |
| title_sort |
quantitative modeling of cerenkov light production efficiency from medical radionuclides |
| description |
There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency and other characteristics of the CR produced by various radionuclides would help in accessing the feasibility of proposed applications and guide the choice of radionuclides. To generate this information we developed models of CR production efficiency based on the Frank-Tamm equation and models of CR distribution based on Monte-Carlo simulations of photon and β particle transport. All models were validated against direct measurements using multiple radionuclides and then applied to a number of radionuclides commonly used in biomedical applications. We show that two radionuclides, Ac-225 and In-111, which have been reported to produce CR in water, do not in fact produce CR directly. We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use. |
| publisher |
Public Library of Science |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282695/ |
| _version_ |
1611507081530048512 |