M cell-depletion blocks oral prion disease pathogenesis
Many prion diseases are orally acquired. Our data show that after oral exposure, early prion replication upon follicular dendritic cells (FDC) in Peyer's patches is obligatory for the efficient spread of disease to the brain (termed neuroinvasion). For prions to replicate on FDC within Peyer�...
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Nature Publishing Group
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282432/ |