Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist
Macitentan is a dual endothelin receptor antagonist under phase 3 investigation in pulmonary arterial hypertension. We investigated the effect of cyclosporine (Cs) and rifampin on the pharmacokinetics of macitentan and its metabolites ACT-132577 and ACT-373898 in healthy male subjects. In addition,...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer US
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282010/ |