The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells
Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation can be attributed to the presence of a junctional complex between adjace...
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| Format: | Online |
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MDPI
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280511/ |
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pubmed-32805112012-02-21 The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells Delorme-Axford, Elizabeth Coyne, Carolyn B. Review Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation can be attributed to the presence of a junctional complex between adjacent cells and to an intricate network of actin filaments that provides support to the subapical membrane and stabilizes intercellular junctions. It is therefore not surprising that many viruses have evolved highly varied strategies to dissolve or modulate the cortical actin meshwork to promote infection of polarized cells. In this review, we will discuss the cell biological properties of the actin cytoskeleton in polarized epithelial cells and review the known mechanisms utilized by viral pathogens to manipulate this system in order to facilitate their infection. MDPI 2011-12-21 /pmc/articles/PMC3280511/ /pubmed/22355449 http://dx.doi.org/10.3390/v3122462 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Delorme-Axford, Elizabeth Coyne, Carolyn B. |
| spellingShingle |
Delorme-Axford, Elizabeth Coyne, Carolyn B. The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells |
| author_facet |
Delorme-Axford, Elizabeth Coyne, Carolyn B. |
| author_sort |
Delorme-Axford, Elizabeth |
| title |
The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells |
| title_short |
The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells |
| title_full |
The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells |
| title_fullStr |
The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells |
| title_full_unstemmed |
The Actin Cytoskeleton as a Barrier to Virus Infection of Polarized Epithelial Cells |
| title_sort |
actin cytoskeleton as a barrier to virus infection of polarized epithelial cells |
| description |
Many diverse viruses target a polarized epithelial monolayer during host invasion. The polarized epithelium is adept at restricting the movement of solutes, ions, macromolecules, and pathogens across the mucosa. This regulation can be attributed to the presence of a junctional complex between adjacent cells and to an intricate network of actin filaments that provides support to the subapical membrane and stabilizes intercellular junctions. It is therefore not surprising that many viruses have evolved highly varied strategies to dissolve or modulate the cortical actin meshwork to promote infection of polarized cells. In this review, we will discuss the cell biological properties of the actin cytoskeleton in polarized epithelial cells and review the known mechanisms utilized by viral pathogens to manipulate this system in order to facilitate their infection. |
| publisher |
MDPI |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280511/ |
| _version_ |
1611506400346767360 |