Population structure of gut Escherichia coli and its role in development of extra-intestinal infections

Extra-intestinal pathogenic Escherichia coli (ExPEC) strains are divided into uropathogenic E. coli (UPEC), strains causing neonatal meningitis and septicaemic E. coli. The most common pathotype of ExPEC is found among patients with urinary tract infection (UTI), defined as UPEC. These bacteria are...

Full description

Bibliographic Details
Main Author:	Katouli, Mohammad
Format:	Online
Language:	English
Published:	Tehran University of Medical Sciences 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279776/

id	pubmed-3279776
recordtype	oai_dc
spelling	pubmed-32797762012-02-16 Population structure of gut Escherichia coli and its role in development of extra-intestinal infections Katouli, Mohammad Review Article Extra-intestinal pathogenic Escherichia coli (ExPEC) strains are divided into uropathogenic E. coli (UPEC), strains causing neonatal meningitis and septicaemic E. coli. The most common pathotype of ExPEC is found among patients with urinary tract infection (UTI), defined as UPEC. These bacteria are responsible for >90% of cases of UTI and are often found amongst the faecal flora of the same host. E.coli strains are classified into four phylogenetic groups, A, B1, B2, and D. Groups A and B1 are commensal strains and carry few virulence-associated genes (VGs) while pathogenic group B2 and D usually possess VGs which enhance colonic persistence and adhesion in the urinary tract (UT). The gastrointestinal (GI) tract is widely accepted as a reservoir for UPEC and is believed that healthy humans have a reservoir of UPEC strains, belonging to phylogenetic group B2, and to a lesser extent, group D. These strains have superior ability to survive and persist in the gut of humans and can spread to cause extra-intestinal infections. ExPEC trains possess a range of VGs which are involved in their pathogenesis. These include adhesins, toxins, iron-acquisition systems (e.g. siderophores), and capsules. Evolutionary influences on the acquisition and main role of VGs amongst E. coli are widely debated, with some research holding that the prevalence of strains with VGs increases the likelihood of infections, whereas others believe that VGs provide a selective advantage for infection of extra-intestinal sites. This review is intended to present our existing knowledge and gaps in this area. Tehran University of Medical Sciences 2010-06 /pmc/articles/PMC3279776/ /pubmed/22347551 Text en © 2010 Iranian Society of Microbiology & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Katouli, Mohammad
spellingShingle	Katouli, Mohammad Population structure of gut Escherichia coli and its role in development of extra-intestinal infections
author_facet	Katouli, Mohammad
author_sort	Katouli, Mohammad
title	Population structure of gut Escherichia coli and its role in development of extra-intestinal infections
title_short	Population structure of gut Escherichia coli and its role in development of extra-intestinal infections
title_full	Population structure of gut Escherichia coli and its role in development of extra-intestinal infections
title_fullStr	Population structure of gut Escherichia coli and its role in development of extra-intestinal infections
title_full_unstemmed	Population structure of gut Escherichia coli and its role in development of extra-intestinal infections
title_sort	population structure of gut escherichia coli and its role in development of extra-intestinal infections
description	Extra-intestinal pathogenic Escherichia coli (ExPEC) strains are divided into uropathogenic E. coli (UPEC), strains causing neonatal meningitis and septicaemic E. coli. The most common pathotype of ExPEC is found among patients with urinary tract infection (UTI), defined as UPEC. These bacteria are responsible for >90% of cases of UTI and are often found amongst the faecal flora of the same host. E.coli strains are classified into four phylogenetic groups, A, B1, B2, and D. Groups A and B1 are commensal strains and carry few virulence-associated genes (VGs) while pathogenic group B2 and D usually possess VGs which enhance colonic persistence and adhesion in the urinary tract (UT). The gastrointestinal (GI) tract is widely accepted as a reservoir for UPEC and is believed that healthy humans have a reservoir of UPEC strains, belonging to phylogenetic group B2, and to a lesser extent, group D. These strains have superior ability to survive and persist in the gut of humans and can spread to cause extra-intestinal infections. ExPEC trains possess a range of VGs which are involved in their pathogenesis. These include adhesins, toxins, iron-acquisition systems (e.g. siderophores), and capsules. Evolutionary influences on the acquisition and main role of VGs amongst E. coli are widely debated, with some research holding that the prevalence of strains with VGs increases the likelihood of infections, whereas others believe that VGs provide a selective advantage for infection of extra-intestinal sites. This review is intended to present our existing knowledge and gaps in this area.
publisher	Tehran University of Medical Sciences
publishDate	2010
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279776/
_version_	1611506135465984000

Population structure of gut Escherichia coli and its role in development of extra-intestinal infections

Similar Items