NADPH Phagocyte Oxidase Knockout Mice Control Trypanosoma cruzi Proliferation, but Develop Circulatory Collapse and Succumb to Infection
•NO is considered to be a key macrophage-derived cytotoxic effector during Trypanosoma cruzi infection. On the other hand, the microbicidal properties of reactive oxygen species (ROS) are well recognized, but little importance has been attributed to them during in vivo infection with T. cruzi. In o...
Main Authors: | Santiago, Helton C., Gonzalez Lombana, Claudia Z., Macedo, Juan P., Utsch, Lara, Tafuri, Wagner L., Campagnole-Santos, Maria José, Alves, Rosana O., Alves-Filho, José C. F., Romanha, Alvaro J., Cunha, Fernando Queiroz, Teixeira, Mauro M., Radi, Rafael, Vieira, Leda Q. |
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Format: | Online |
Language: | English |
Published: |
Public Library of Science
2012
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279332/ |
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