Radiation techniques for acromegaly
Radiotherapy (RT) remains an effective treatment in patients with acromegaly refractory to medical and/or surgical interventions, with durable tumor control and biochemical remission; however, there are still concerns about delayed biochemical effect and potential late toxicity of radiation treatmen...
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BioMed Central
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275813/ |
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pubmed-32758132012-02-09 Radiation techniques for acromegaly Minniti, Giuseppe Scaringi, Claudia Enrici, Riccardo Maurizi Review Radiotherapy (RT) remains an effective treatment in patients with acromegaly refractory to medical and/or surgical interventions, with durable tumor control and biochemical remission; however, there are still concerns about delayed biochemical effect and potential late toxicity of radiation treatment, especially high rates of hypopituitarism. Stereotactic radiotherapy has been developed as a more accurate technique of irradiation with more precise tumour localization and consequently a reduction in the volume of normal tissue, particularly the brain, irradiated to high radiation doses. Radiation can be delivered in a single fraction by stereotactic radiosurgery (SRS) or as fractionated stereotactic radiotherapy (FSRT) in which smaller doses are delivered over 5-6 weeks in 25-30 treatments. A review of the recent literature suggests that pituitary irradiation is an effective treatment for acromegaly. Stereotactic techniques for GH-secreting pituitary tumors are discussed with the aim to define the efficacy and potential adverse effects of each of these techniques. BioMed Central 2011-12-02 /pmc/articles/PMC3275813/ /pubmed/22136376 http://dx.doi.org/10.1186/1748-717X-6-167 Text en Copyright ©2011 Minniti et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Minniti, Giuseppe Scaringi, Claudia Enrici, Riccardo Maurizi |
| spellingShingle |
Minniti, Giuseppe Scaringi, Claudia Enrici, Riccardo Maurizi Radiation techniques for acromegaly |
| author_facet |
Minniti, Giuseppe Scaringi, Claudia Enrici, Riccardo Maurizi |
| author_sort |
Minniti, Giuseppe |
| title |
Radiation techniques for acromegaly |
| title_short |
Radiation techniques for acromegaly |
| title_full |
Radiation techniques for acromegaly |
| title_fullStr |
Radiation techniques for acromegaly |
| title_full_unstemmed |
Radiation techniques for acromegaly |
| title_sort |
radiation techniques for acromegaly |
| description |
Radiotherapy (RT) remains an effective treatment in patients with acromegaly refractory to medical and/or surgical interventions, with durable tumor control and biochemical remission; however, there are still concerns about delayed biochemical effect and potential late toxicity of radiation treatment, especially high rates of hypopituitarism. Stereotactic radiotherapy has been developed as a more accurate technique of irradiation with more precise tumour localization and consequently a reduction in the volume of normal tissue, particularly the brain, irradiated to high radiation doses. Radiation can be delivered in a single fraction by stereotactic radiosurgery (SRS) or as fractionated stereotactic radiotherapy (FSRT) in which smaller doses are delivered over 5-6 weeks in 25-30 treatments. A review of the recent literature suggests that pituitary irradiation is an effective treatment for acromegaly. Stereotactic techniques for GH-secreting pituitary tumors are discussed with the aim to define the efficacy and potential adverse effects of each of these techniques. |
| publisher |
BioMed Central |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275813/ |
| _version_ |
1611504977813962752 |