Structures, Substrates, and Regulators of Mammalian Sirtuins – Opportunities and Challenges for Drug Development
Sirtuins are NAD+-dependent protein deacetylases regulating metabolism, stress responses, and aging processes. Mammalia have seven Sirtuin isoforms, Sirt1–7, which differ in their substrate specificities and subcellular localizations. The physiological functions of Sirtuins make them interesting the...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Frontiers Research Foundation
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275776/ |