BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System

BACE1 is a key enzyme for amyloid-β (Aβ) production, and an attractive therapeutic target in Alzheimer's disease (AD). Here we report that BACE1 inhibitors have distinct effects on neuronal Aβ metabolism, inducing a unique pattern of secreted Aβ peptides, analyzed in cell media from amyloid pre...

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Bibliographic Details
Main Authors: Mattsson, Niklas, Rajendran, Lawrence, Zetterberg, Henrik, Gustavsson, Mikael, Andreasson, Ulf, Olsson, Maria, Brinkmalm, Gunnar, Lundkvist, Johan, Jacobson, Laura H., Perrot, Ludovic, Neumann, Ulf, Borghys, Herman, Mercken, Marc, Dhuyvetter, Deborah, Jeppsson, Fredrik, Blennow, Kaj, Portelius, Erik
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273469/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273469/

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