MicroRNA Control of Invasion and Metastasis Pathways
Despite recent advances, cancer remains a leading cause of death worldwide. In developed countries, the incidence of colorectal and breast cancer has been stable, but no improvement in prognosis has been observed if the patient presents with metastases at diagnosis. This fact highlights the importan...
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Frontiers Research Foundation
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268611/ |
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pubmed-32686112012-02-02 MicroRNA Control of Invasion and Metastasis Pathways Sreekumar, Rahul Sayan, Berna S. Mirnezami, Alex H. Sayan, A. Emre Genetics Despite recent advances, cancer remains a leading cause of death worldwide. In developed countries, the incidence of colorectal and breast cancer has been stable, but no improvement in prognosis has been observed if the patient presents with metastases at diagnosis. This fact highlights the importance of therapeutic approaches targeting cellular invasion and metastasis programs as the next step in cancer treatment. During carcinoma progression a process called epithelial–mesenchymal transition (EMT) results in enhanced invasion and motility which is directly linked with loss of epithelial polarity and epithelial junctions, migration permissive cytoskeleton alterations, and the acquisition of mesenchymal properties. The recent discovery of microRNAs (miRNAs) controlling key cellular pathways has opened a new era in understanding how EMT pathways are modulated. In this review, we classify EMT regulating proteins according to their cellular localization (membrane, cytoplasmic, and nuclear), and summarize the current knowledge on how they are controlled by miRNAs and propose potential miRNAs for the transcripts that may control their expression. Frontiers Research Foundation 2011-09-05 /pmc/articles/PMC3268611/ /pubmed/22303353 http://dx.doi.org/10.3389/fgene.2011.00058 Text en Copyright © 2011 Sreekumar, Sayan, Mirnezami and Sayan. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sreekumar, Rahul Sayan, Berna S. Mirnezami, Alex H. Sayan, A. Emre |
| spellingShingle |
Sreekumar, Rahul Sayan, Berna S. Mirnezami, Alex H. Sayan, A. Emre MicroRNA Control of Invasion and Metastasis Pathways |
| author_facet |
Sreekumar, Rahul Sayan, Berna S. Mirnezami, Alex H. Sayan, A. Emre |
| author_sort |
Sreekumar, Rahul |
| title |
MicroRNA Control of Invasion and Metastasis Pathways |
| title_short |
MicroRNA Control of Invasion and Metastasis Pathways |
| title_full |
MicroRNA Control of Invasion and Metastasis Pathways |
| title_fullStr |
MicroRNA Control of Invasion and Metastasis Pathways |
| title_full_unstemmed |
MicroRNA Control of Invasion and Metastasis Pathways |
| title_sort |
microrna control of invasion and metastasis pathways |
| description |
Despite recent advances, cancer remains a leading cause of death worldwide. In developed countries, the incidence of colorectal and breast cancer has been stable, but no improvement in prognosis has been observed if the patient presents with metastases at diagnosis. This fact highlights the importance of therapeutic approaches targeting cellular invasion and metastasis programs as the next step in cancer treatment. During carcinoma progression a process called epithelial–mesenchymal transition (EMT) results in enhanced invasion and motility which is directly linked with loss of epithelial polarity and epithelial junctions, migration permissive cytoskeleton alterations, and the acquisition of mesenchymal properties. The recent discovery of microRNAs (miRNAs) controlling key cellular pathways has opened a new era in understanding how EMT pathways are modulated. In this review, we classify EMT regulating proteins according to their cellular localization (membrane, cytoplasmic, and nuclear), and summarize the current knowledge on how they are controlled by miRNAs and propose potential miRNAs for the transcripts that may control their expression. |
| publisher |
Frontiers Research Foundation |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268611/ |
| _version_ |
1611502784613449728 |