Quantitating subcellular metabolism with multi-isotope imaging mass spectrometry

Mass spectrometry with stable isotope labels has been seminal in discovering the dynamic state of living matter1,2 but is limited to bulk tissues or cells. We developed multi-isotope imaging mass spectrometry (MIMS) that allowed us to view and measure stable isotope incorporation with sub-micron res...

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Bibliographic Details
Main Authors: Steinhauser, Matthew L., Bailey, Andrew, Senyo, Samuel E., Guillermier, Christelle, Perlstein, Todd S., Gould, Alex P., Lee, Richard T., Lechene, Claude P.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267887/