High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting

The ability to track microbes in real time in vivo is of enormous value for preclinical investigations in infectious disease or gene therapy research. Bacteria present an attractive class of vector for cancer therapy, possessing a natural ability to grow preferentially within tumours following syste...

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Main Authors:	Cronin, Michelle, Akin, Ali R., Collins, Sara A., Meganck, Jeff, Kim, Jae-Beom, Baban, Chwanrow K., Joyce, Susan A., van Dam, Gooitzen M., Zhang, Ning, van Sinderen, Douwe, O'Sullivan, Gerald C., Kasahara, Noriyuki, Gahan, Cormac G., Francis, Kevin P., Tangney, Mark
Format:	Online
Language:	English
Published:	Public Library of Science 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266281/

id	pubmed-3266281
recordtype	oai_dc
spelling	pubmed-32662812012-01-31 High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting Cronin, Michelle Akin, Ali R. Collins, Sara A. Meganck, Jeff Kim, Jae-Beom Baban, Chwanrow K. Joyce, Susan A. van Dam, Gooitzen M. Zhang, Ning van Sinderen, Douwe O'Sullivan, Gerald C. Kasahara, Noriyuki Gahan, Cormac G. Francis, Kevin P. Tangney, Mark Research Article The ability to track microbes in real time in vivo is of enormous value for preclinical investigations in infectious disease or gene therapy research. Bacteria present an attractive class of vector for cancer therapy, possessing a natural ability to grow preferentially within tumours following systemic administration. Bioluminescent Imaging (BLI) represents a powerful tool for use with bacteria engineered to express reporter genes such as lux. BLI is traditionally used as a 2D modality resulting in images that are limited in their ability to anatomically locate cell populations. Use of 3D diffuse optical tomography can localize the signals but still need to be combined with an anatomical imaging modality like micro-Computed Tomography (μCT) for interpretation. Public Library of Science 2012-01-25 /pmc/articles/PMC3266281/ /pubmed/22295120 http://dx.doi.org/10.1371/journal.pone.0030940 Text en Cronin et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Cronin, Michelle Akin, Ali R. Collins, Sara A. Meganck, Jeff Kim, Jae-Beom Baban, Chwanrow K. Joyce, Susan A. van Dam, Gooitzen M. Zhang, Ning van Sinderen, Douwe O'Sullivan, Gerald C. Kasahara, Noriyuki Gahan, Cormac G. Francis, Kevin P. Tangney, Mark
spellingShingle	Cronin, Michelle Akin, Ali R. Collins, Sara A. Meganck, Jeff Kim, Jae-Beom Baban, Chwanrow K. Joyce, Susan A. van Dam, Gooitzen M. Zhang, Ning van Sinderen, Douwe O'Sullivan, Gerald C. Kasahara, Noriyuki Gahan, Cormac G. Francis, Kevin P. Tangney, Mark High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting
author_facet	Cronin, Michelle Akin, Ali R. Collins, Sara A. Meganck, Jeff Kim, Jae-Beom Baban, Chwanrow K. Joyce, Susan A. van Dam, Gooitzen M. Zhang, Ning van Sinderen, Douwe O'Sullivan, Gerald C. Kasahara, Noriyuki Gahan, Cormac G. Francis, Kevin P. Tangney, Mark
author_sort	Cronin, Michelle
title	High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting
title_short	High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting
title_full	High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting
title_fullStr	High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting
title_full_unstemmed	High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting
title_sort	high resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting
description	The ability to track microbes in real time in vivo is of enormous value for preclinical investigations in infectious disease or gene therapy research. Bacteria present an attractive class of vector for cancer therapy, possessing a natural ability to grow preferentially within tumours following systemic administration. Bioluminescent Imaging (BLI) represents a powerful tool for use with bacteria engineered to express reporter genes such as lux. BLI is traditionally used as a 2D modality resulting in images that are limited in their ability to anatomically locate cell populations. Use of 3D diffuse optical tomography can localize the signals but still need to be combined with an anatomical imaging modality like micro-Computed Tomography (μCT) for interpretation.
publisher	Public Library of Science
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266281/
_version_	1611502219464540160

High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting

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