Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia

This report shows that the DNA-binding drug, mithramycin, can be efficiently encapsulated in polymeric micelles (PM-MTH), based on Pluronic® block copolymers, by a new microfluidic approach. The effect of different production parameters has been investigated for their effect on PM-MTH characteristic...

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Bibliographic Details
Main Authors: Capretto, Lorenzo, Mazzitelli, Stefania, Brognara, Eleonora, Lampronti, Ilaria, Carugo, Dario, Hill, Martyn, Zhang, Xunli, Gambari, Roberto, Nastruzzi, Claudio
Format: Online
Language:English
Published: Dove Medical Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265999/