Beltless Translocation Domain of Botulinum Neurotoxin A Embodies a Minimum Ion-conductive Channel*

Background: A key step in intoxication by botulinum neurotoxins is the translocation of the protease domain by the translocation domain (TD) across endosomes. The requirements for translocation remain poorly understood.

Bibliographic Details
Main Authors: Fischer, Audrey, Sambashivan, Shilpa, Brunger, Axel T., Montal, Mauricio
Format: Online
Language:English
Published: American Society for Biochemistry and Molecular Biology 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265847/