Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection
Xenotropic murine leukemia virus-related virus (XMRV) is a newly identified gamma retrovirus and may be associated with prostate cancer- (PC) and chronic fatigue syndrome (CFS). Since its identification in 2006 and detection of polytropic murine lenkemia virus (MLV)-like sequences in CFS patients in...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265300/ |
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pubmed-3265300 |
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pubmed-32653002012-02-06 Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection Tang, Shixing Hewlett, Indira K. Review Article Xenotropic murine leukemia virus-related virus (XMRV) is a newly identified gamma retrovirus and may be associated with prostate cancer- (PC) and chronic fatigue syndrome (CFS). Since its identification in 2006 and detection of polytropic murine lenkemia virus (MLV)-like sequences in CFS patients in 2010, several test methods including nucleic acid testing methods and serological assays have been developed for detection of XMRV and/or MLV-like sequences. However, these research assays have not yet been validated and evaluated due to the lack of well-characterized reference materials. Mouse DNA contamination should be carefully checked when testing human specimens in order to avoid false-positive detection of XMRV or MLV-like sequences. Hindawi Publishing Corporation 2011 2011-07-28 /pmc/articles/PMC3265300/ /pubmed/22312340 http://dx.doi.org/10.1155/2011/281425 Text en Copyright © 2011 S. Tang and I. K. Hewlett. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Tang, Shixing Hewlett, Indira K. |
| spellingShingle |
Tang, Shixing Hewlett, Indira K. Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| author_facet |
Tang, Shixing Hewlett, Indira K. |
| author_sort |
Tang, Shixing |
| title |
Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_short |
Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_full |
Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_fullStr |
Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_full_unstemmed |
Testing Strategies for Detection of Xenotropic Murine Leukemia Virus-Related Virus Infection |
| title_sort |
testing strategies for detection of xenotropic murine leukemia virus-related virus infection |
| description |
Xenotropic murine leukemia virus-related virus (XMRV) is a newly identified gamma retrovirus and may be associated with prostate cancer- (PC) and chronic fatigue syndrome (CFS). Since its identification in 2006 and detection of polytropic murine lenkemia virus (MLV)-like sequences in CFS patients in 2010, several test methods including nucleic acid testing methods and serological assays have been developed for detection of XMRV and/or MLV-like sequences. However, these research assays have not yet been validated and evaluated due to the lack of well-characterized reference materials. Mouse DNA contamination should be carefully checked when testing human specimens in order to avoid false-positive detection of XMRV or MLV-like sequences. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265300/ |
| _version_ |
1611501978799570944 |