Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique

Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique

The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 32 full factorial design. The ratio of HPMC K4M and PVP K30 (X 1) and the concentration of melt binder (X...

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Main Authors: Prajapati, Shailesh T., Patel, Amit N., Patel, Chhagan N.
Format: Online
Language:English
Published: International Scholarly Research Network 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263716/
id pubmed-3263716
recordtype oai_dc
spelling pubmed-32637162012-03-02 Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique Prajapati, Shailesh T. Patel, Amit N. Patel, Chhagan N. Research Article The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 32 full factorial design. The ratio of HPMC K4M and PVP K30 (X 1) and the concentration of melt binder (X 2) were selected as independent variables, and drug release at 1 hr (Q 1), 4 hr (Q 4), 8 hr (Q 8), diffusion coefficient (n), and release rate constant (K) were selected as a dependent variable. Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters. It was observed that concentration of melt binder had significant effect on Q 1, Q 4, n, and K Binder concentration 25% w/w was found optimum. Optimized formulation (F 7) showed good similarity with theoretical profile of drug. The X 2 variable had a significant effect on dependent variables, and the X 1 variable had no significant effect on dependent variables. International Scholarly Research Network 2011 2011-06-27 /pmc/articles/PMC3263716/ /pubmed/22389845 http://dx.doi.org/10.5402/2011/208394 Text en Copyright © 2011 Shailesh T. Prajapati et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Prajapati, Shailesh T.
Patel, Amit N.
Patel, Chhagan N.
spellingShingle Prajapati, Shailesh T.
Patel, Amit N.
Patel, Chhagan N.
Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
author_facet Prajapati, Shailesh T.
Patel, Amit N.
Patel, Chhagan N.
author_sort Prajapati, Shailesh T.
title Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
title_short Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
title_full Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
title_fullStr Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
title_full_unstemmed Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique
title_sort formulation and evaluation of controlled-release tablet of zolpidem tartrate by melt granulation technique
description The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 32 full factorial design. The ratio of HPMC K4M and PVP K30 (X 1) and the concentration of melt binder (X 2) were selected as independent variables, and drug release at 1 hr (Q 1), 4 hr (Q 4), 8 hr (Q 8), diffusion coefficient (n), and release rate constant (K) were selected as a dependent variable. Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters. It was observed that concentration of melt binder had significant effect on Q 1, Q 4, n, and K Binder concentration 25% w/w was found optimum. Optimized formulation (F 7) showed good similarity with theoretical profile of drug. The X 2 variable had a significant effect on dependent variables, and the X 1 variable had no significant effect on dependent variables.
publisher International Scholarly Research Network
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263716/
_version_ 1611501600770097152

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