Familial Parkinson's Disease Mutant E46K α-Synuclein Localizes to Membranous Structures, Forms Aggregates, and Induces Toxicity in Yeast Models

Familial Parkinson's Disease Mutant E46K α-Synuclein Localizes to Membranous Structures, Forms Aggregates, and Induces Toxicity in Yeast Models

In Parkinson's disease (PD), midbrain dopaminergic neuronal death is linked to the accumulation of aggregated α-synuclein. The familial PD mutant form of α-synuclein, E46K, has not been thoroughly evaluated yet in an organismal model system. Here, we report that E46K resembled wild-type (WT) α-...

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Bibliographic Details
Main Authors: Fiske, Michael, White, Michael, Valtierra, Stephanie, Herrera, Sara, Solvang, Keith, Konnikova, Alina, DebBurman, Shubhik
Format: Online
Language:English
Published: International Scholarly Research Network 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263534/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263534/

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