cGMP Signaling, Phosphodiesterases and Major Depressive Disorder

Deficits in neuroplasticity are hypothesized to underlie the pathophysiology of major depressive disorder (MDD): the effectiveness of antidepressants is thought to be related to the normalization of disrupted synaptic transmission and neurogenesis. The cyclic adenosine monophosphate (cAMP) signaling...

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Bibliographic Details
Main Authors: Reierson, Gillian W, Guo, Shuyu, Mastronardi, Claudio, Licinio, Julio, Wong, Ma-Li
Format: Online
Language:English
Published: Bentham Science Publishers 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263465/