Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?

Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?

Sentinel lymph node biopsy (SLNB) is a safe and accurate minimally invasive method for detecting axillary lymph node (ALN) involvement in the clinically negative axilla thereby reducing morbidity in patients who avoid unnecessary axillary lymph node dissection (ALND). Although current guidelines rec...

Full description

Bibliographic Details
Main Authors: Pazaiti, Anastasia, Fentiman, Ian S.
Format: Online
Language:English
Published: SAGE-Hindawi Access to Research 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262558/
id pubmed-3262558
recordtype oai_dc
spelling pubmed-32625582012-01-31 Which Patients Need an Axillary Clearance after Sentinel Node Biopsy? Pazaiti, Anastasia Fentiman, Ian S. Review Article Sentinel lymph node biopsy (SLNB) is a safe and accurate minimally invasive method for detecting axillary lymph node (ALN) involvement in the clinically negative axilla thereby reducing morbidity in patients who avoid unnecessary axillary lymph node dissection (ALND). Although current guidelines recommend completion ALND when macro- and micrometastatic diseases are identified by SLNB, the benefit of this surgical intervention is under debate. Additionally, the management of the axilla in the presence of isolated tumour cells (ITCs) in SLNB is questioned. Particularly controversial is the prognostic significance of minimal SLNB metastasis in relation to local recurrence and overall survival. Preliminary results of the recently published Z0011 trial suggest similar outcomes after SNB or ALND when the SN is positive, but this finding has to be interpreted with caution. SAGE-Hindawi Access to Research 2011 2011-08-24 /pmc/articles/PMC3262558/ /pubmed/22295211 http://dx.doi.org/10.4061/2011/195892 Text en Copyright © 2011 A. Pazaiti and I. S. Fentiman. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Pazaiti, Anastasia
Fentiman, Ian S.
spellingShingle Pazaiti, Anastasia
Fentiman, Ian S.
Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?
author_facet Pazaiti, Anastasia
Fentiman, Ian S.
author_sort Pazaiti, Anastasia
title Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?
title_short Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?
title_full Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?
title_fullStr Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?
title_full_unstemmed Which Patients Need an Axillary Clearance after Sentinel Node Biopsy?
title_sort which patients need an axillary clearance after sentinel node biopsy?
description Sentinel lymph node biopsy (SLNB) is a safe and accurate minimally invasive method for detecting axillary lymph node (ALN) involvement in the clinically negative axilla thereby reducing morbidity in patients who avoid unnecessary axillary lymph node dissection (ALND). Although current guidelines recommend completion ALND when macro- and micrometastatic diseases are identified by SLNB, the benefit of this surgical intervention is under debate. Additionally, the management of the axilla in the presence of isolated tumour cells (ITCs) in SLNB is questioned. Particularly controversial is the prognostic significance of minimal SLNB metastasis in relation to local recurrence and overall survival. Preliminary results of the recently published Z0011 trial suggest similar outcomes after SNB or ALND when the SN is positive, but this finding has to be interpreted with caution.
publisher SAGE-Hindawi Access to Research
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262558/
_version_ 1611501157793923072

Similar Items