RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside triphosphates (dNTPs) during replication. Misincorporation is limited by the selectivity of DNA replicases. We show that accumulation of ribonu...

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Bibliographic Details
Main Authors: Lazzaro, Federico, Novarina, Daniele, Amara, Flavio, Watt, Danielle L., Stone, Jana E., Costanzo, Vincenzo, Burgers, Peter M., Kunkel, Thomas A., Plevani, Paolo, Muzi-Falconi, Marco
Format: Online
Language:English
Published: Cell Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262129/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262129/

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