Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

Early after symptom onset, HCV-specific CD4+ T cell responses are primed and detectable in patients regardless of clinical outcome, but without early antiviral therapy these T cells become exhausted or deleted in chronically infected patients.

Bibliographic Details
Main Authors: Schulze zur Wiesch, Julian, Ciuffreda, Donatella, Lewis-Ximenez, Lia, Kasprowicz, Victoria, Nolan, Brian E., Streeck, Hendrik, Aneja, Jasneet, Reyor, Laura L., Allen, Todd M., Lohse, Ansgar W., McGovern, Barbara, Chung, Raymond T., Kwok, William W., Kim, Arthur Y., Lauer, Georg M.
Format: Online
Language:English
Published: The Rockefeller University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260872/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260872/

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