MetalionRNA: computational predictor of metal-binding sites in RNA structures

Motivation: Metal ions are essential for the folding of RNA molecules into stable tertiary structures and are often involved in the catalytic activity of ribozymes. However, the positions of metal ions in RNA 3D structures are difficult to determine experimentally. This motivated us to develop a com...

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Bibliographic Details
Main Authors: Philips, Anna, Milanowska, Kaja, Lach, Grzegorz, Boniecki, Michal, Rother, Kristian, Bujnicki, Janusz M.
Format: Online
Language:English
Published: Oxford University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259437/
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Summary:Motivation: Metal ions are essential for the folding of RNA molecules into stable tertiary structures and are often involved in the catalytic activity of ribozymes. However, the positions of metal ions in RNA 3D structures are difficult to determine experimentally. This motivated us to develop a computational predictor of metal ion sites for RNA structures.