A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru
In the wake of emerging T. cruzi infection in children of periurban Arequipa, Peru, we conducted a prospective field trial to evaluate alternative targeted screening strategies for Chagas disease across the city. Using insect vector data that is routinely collected during Ministry of Health insectic...
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| Format: | Online |
| Language: | English |
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Public Library of Science
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254655/ |
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pubmed-3254655 |
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pubmed-32546552012-01-17 A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru Hunter, Gabrielle C. Borrini-Mayorí, Katty Ancca Juárez, Jenny Castillo Neyra, Ricardo Verastegui, Manuela R. Malaga Chavez, Fernando S. Cornejo del Carpio, Juan Geny Córdova Benzaquen, Eleazar Náquira, César Gilman, Robert H. Bern, Caryn Levy, Michael Z. Research Article In the wake of emerging T. cruzi infection in children of periurban Arequipa, Peru, we conducted a prospective field trial to evaluate alternative targeted screening strategies for Chagas disease across the city. Using insect vector data that is routinely collected during Ministry of Health insecticide application campaigns in 3 periurban districts of Arequipa, we separated into 4 categories those households with 1) infected vectors; 2) high vector densities; 3) low vector densities; and 4) no vectors. Residents of all infected-vector households and a random sample of those in the other 3 categories were invited for serological screening for T. cruzi infection. Subsequently, all residents of households within a 15-meter radius of detected seropositive individuals were invited to be screened in a ring case-detection scheme. Of 923 participants, 21 (2.28%) were seropositive. There were no significant differences in prevalence across the 4 screening strategies, indicating that household entomologic factors alone could not predict the risk of infection. Indeed, the most predictive variable of infection was the number of years a person lived in a location with triatomine insects. Therefore, a simple residence history questionnaire may be a useful screening tool in large, diverse urban environments with emerging Chagas disease. Public Library of Science 2012-01-10 /pmc/articles/PMC3254655/ /pubmed/22253939 http://dx.doi.org/10.1371/journal.pntd.0001468 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Hunter, Gabrielle C. Borrini-Mayorí, Katty Ancca Juárez, Jenny Castillo Neyra, Ricardo Verastegui, Manuela R. Malaga Chavez, Fernando S. Cornejo del Carpio, Juan Geny Córdova Benzaquen, Eleazar Náquira, César Gilman, Robert H. Bern, Caryn Levy, Michael Z. |
| spellingShingle |
Hunter, Gabrielle C. Borrini-Mayorí, Katty Ancca Juárez, Jenny Castillo Neyra, Ricardo Verastegui, Manuela R. Malaga Chavez, Fernando S. Cornejo del Carpio, Juan Geny Córdova Benzaquen, Eleazar Náquira, César Gilman, Robert H. Bern, Caryn Levy, Michael Z. A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru |
| author_facet |
Hunter, Gabrielle C. Borrini-Mayorí, Katty Ancca Juárez, Jenny Castillo Neyra, Ricardo Verastegui, Manuela R. Malaga Chavez, Fernando S. Cornejo del Carpio, Juan Geny Córdova Benzaquen, Eleazar Náquira, César Gilman, Robert H. Bern, Caryn Levy, Michael Z. |
| author_sort |
Hunter, Gabrielle C. |
| title |
A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru |
| title_short |
A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru |
| title_full |
A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru |
| title_fullStr |
A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru |
| title_full_unstemmed |
A Field Trial of Alternative Targeted Screening Strategies for Chagas Disease in Arequipa, Peru |
| title_sort |
field trial of alternative targeted screening strategies for chagas disease in arequipa, peru |
| description |
In the wake of emerging T. cruzi infection in children of periurban Arequipa, Peru, we conducted a prospective field trial to evaluate alternative targeted screening strategies for Chagas disease across the city. Using insect vector data that is routinely collected during Ministry of Health insecticide application campaigns in 3 periurban districts of Arequipa, we separated into 4 categories those households with 1) infected vectors; 2) high vector densities; 3) low vector densities; and 4) no vectors. Residents of all infected-vector households and a random sample of those in the other 3 categories were invited for serological screening for T. cruzi infection. Subsequently, all residents of households within a 15-meter radius of detected seropositive individuals were invited to be screened in a ring case-detection scheme. Of 923 participants, 21 (2.28%) were seropositive. There were no significant differences in prevalence across the 4 screening strategies, indicating that household entomologic factors alone could not predict the risk of infection. Indeed, the most predictive variable of infection was the number of years a person lived in a location with triatomine insects. Therefore, a simple residence history questionnaire may be a useful screening tool in large, diverse urban environments with emerging Chagas disease. |
| publisher |
Public Library of Science |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254655/ |
| _version_ |
1611499037263921152 |