Association analysis of PARP1 polymorphisms with Parkinson’s disease

Association analysis of PARP1 polymorphisms with Parkinson’s disease

Alpha-synuclein accumulation in intracellular inclusions, oxidative stress and microglia-mediated inflammation in the substantia nigra are crucial events in the pathogenesis of Parkinson’s disease (PD). Poly (ADP-ribose) polymerase-1 (PARP1), a DNA-binding enzyme and transcriptional regulator, plays...

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Bibliographic Details
Main Authors: Brighina, Laura, Riva, Chiara, Bertola, Francesca, Fermi, Silvia, Saracchi, Enrico, Piolti, Roberto, Goldwurm, Stefano, Pezzoli, Gianni, Ferrarese, Carlo
Format: Online
Language:English
Published: Elsevier Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254239/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254239/

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