Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression

Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression

Naturally SIV-infected sooty mangabeys (SMs) do not progress to AIDS despite high-level virus replication. We previously showed that the fraction of CD4+CCR5+ T-cells is lower in SMs compared to humans and macaques. Here we found that, after in vitro stimulation, SM CD4+ T-cells fail to up-regulate...

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Bibliographic Details
Main Authors: Paiardini, Mirko, Cervasi, Barbara, Reyes-Aviles, Elane, Micci, Luca, Ortiz, Alexandra M., Chahroudi, Ann, Vinton, Carol, Gordon, Shari N., Bosinger, Steven E., Francella, Nicholas, Hallberg, Paul L., Schlub, Timothy, Chan, Ming Liang, Riddick, Nadeene E., Collman, Ronald G., Apetrei, Cristian, Pandrea, Ivona, Else, James, Munch, Jan, Kirchhoff, Frank, Davenport, Miles P., Brenchley, Jason M., Silvestri, Guido
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253129/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253129/

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