Trihydrophobin 1 Phosphorylation by c-Src Regulates MAPK/ERK Signaling and Cell Migration

Trihydrophobin 1 Phosphorylation by c-Src Regulates MAPK/ERK Signaling and Cell Migration

c-Src activates Ras-MAPK/ERK signaling pathway and regulates cell migration, while trihydrophobin 1 (TH1) inhibits MAPK/ERK activation and cell migration through interaction with A-Raf and PAK1 and inhibiting their kinase activities. Here we show that c-Src interacts with TH1 by GST-pull down assay,...

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Bibliographic Details
Main Authors: Wu, Weibin, Sun, Zhichao, Wu, Jingwen, Peng, Xiaomin, Gan, Huacheng, Zhang, Chunyi, Ji, Lingling, Xie, Jianhui, Zhu, Haiyan, Ren, Shifang, Gu, Jianxin, Zhang, Songwen
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253115/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253115/

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