Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia

Disruption of fronto-temporal connections involving the arcuate fasciculus (AF) may underlie language processing anomalies and psychotic features such as auditory hallucinations in schizophrenia. No study to date has specifically investigated abnormalities of white matter integrity at particular loc...

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Main Authors:	Abdul-Rahman, Muhammad Farid, Qiu, Anqi, Woon, Puay San, Kuswanto, Carissa, Collinson, Simon L., Sim, Kang
Format:	Online
Language:	English
Published:	Public Library of Science 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252319/

id	pubmed-3252319
recordtype	oai_dc
spelling	pubmed-32523192012-01-12 Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia Abdul-Rahman, Muhammad Farid Qiu, Anqi Woon, Puay San Kuswanto, Carissa Collinson, Simon L. Sim, Kang Research Article Disruption of fronto-temporal connections involving the arcuate fasciculus (AF) may underlie language processing anomalies and psychotic features such as auditory hallucinations in schizophrenia. No study to date has specifically investigated abnormalities of white matter integrity at particular loci along the AF as well as its regional lateralization in schizophrenia. We examined white matter changes (fractional anisotropy (FA), axial diffusivity (AD), asymmetry indices) along the whole extent of the AF and their relationship with psychotic symptoms in 32 males with schizophrenia and 44 healthy males. Large deformation diffeomorphic metric mapping and Fiber Assignment Continuous Tracking were employed to characterize FA and AD along the geometric curve of the AF. Our results showed that patients with schizophrenia had lower FA in the frontal aspects of the left AF compared with healthy controls. Greater left FA and AD lateralization in the temporal segment of AF were associated with more severe positive psychotic symptoms such as delusions and hallucinations in patients with schizophrenia. Disruption of white matter integrity of the left frontal AF and accentuation of normal left greater than right asymmetry of FA/AD in the temporal AF further support the notion of aberrant fronto-temporal connectivity in schizophrenia. AF pathology can affect corollary discharge of neural signals from frontal speech/motor initiation areas to suppress activity of auditory cortex that may influence psychotic phenomena such as auditory hallucinations and facilitate elaboration of delusional content. Public Library of Science 2012-01-05 /pmc/articles/PMC3252319/ /pubmed/22242165 http://dx.doi.org/10.1371/journal.pone.0029315 Text en Abdul-Rahman et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Abdul-Rahman, Muhammad Farid Qiu, Anqi Woon, Puay San Kuswanto, Carissa Collinson, Simon L. Sim, Kang
spellingShingle	Abdul-Rahman, Muhammad Farid Qiu, Anqi Woon, Puay San Kuswanto, Carissa Collinson, Simon L. Sim, Kang Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia
author_facet	Abdul-Rahman, Muhammad Farid Qiu, Anqi Woon, Puay San Kuswanto, Carissa Collinson, Simon L. Sim, Kang
author_sort	Abdul-Rahman, Muhammad Farid
title	Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia
title_short	Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia
title_full	Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia
title_fullStr	Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia
title_full_unstemmed	Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia
title_sort	arcuate fasciculus abnormalities and their relationship with psychotic symptoms in schizophrenia
description	Disruption of fronto-temporal connections involving the arcuate fasciculus (AF) may underlie language processing anomalies and psychotic features such as auditory hallucinations in schizophrenia. No study to date has specifically investigated abnormalities of white matter integrity at particular loci along the AF as well as its regional lateralization in schizophrenia. We examined white matter changes (fractional anisotropy (FA), axial diffusivity (AD), asymmetry indices) along the whole extent of the AF and their relationship with psychotic symptoms in 32 males with schizophrenia and 44 healthy males. Large deformation diffeomorphic metric mapping and Fiber Assignment Continuous Tracking were employed to characterize FA and AD along the geometric curve of the AF. Our results showed that patients with schizophrenia had lower FA in the frontal aspects of the left AF compared with healthy controls. Greater left FA and AD lateralization in the temporal segment of AF were associated with more severe positive psychotic symptoms such as delusions and hallucinations in patients with schizophrenia. Disruption of white matter integrity of the left frontal AF and accentuation of normal left greater than right asymmetry of FA/AD in the temporal AF further support the notion of aberrant fronto-temporal connectivity in schizophrenia. AF pathology can affect corollary discharge of neural signals from frontal speech/motor initiation areas to suppress activity of auditory cortex that may influence psychotic phenomena such as auditory hallucinations and facilitate elaboration of delusional content.
publisher	Public Library of Science
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252319/
_version_	1611498340382408704

Arcuate Fasciculus Abnormalities and Their Relationship with Psychotic Symptoms in Schizophrenia

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