Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study

Examining the spontaneous activity to understand the neural mechanism of brain disorder is a focus in recent resting-state fMRI. In the current study, to investigate the alteration of brain functional connectivity in partial epilepsy in a systematical way, two levels of analyses (functional connecti...

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Main Authors:	Luo, Cheng, Qiu, Chuan, Guo, Zhiwei, Fang, Jiajia, Li, Qifu, Lei, Xu, Xia, Yang, Lai, Yongxiu, Gong, Qiyong, Zhou, Dong, Yao, Dezhong
Format:	Online
Language:	English
Published:	Public Library of Science 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252302/

id	pubmed-3252302
recordtype	oai_dc
spelling	pubmed-32523022012-01-12 Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study Luo, Cheng Qiu, Chuan Guo, Zhiwei Fang, Jiajia Li, Qifu Lei, Xu Xia, Yang Lai, Yongxiu Gong, Qiyong Zhou, Dong Yao, Dezhong Research Article Examining the spontaneous activity to understand the neural mechanism of brain disorder is a focus in recent resting-state fMRI. In the current study, to investigate the alteration of brain functional connectivity in partial epilepsy in a systematical way, two levels of analyses (functional connectivity analysis within resting state networks (RSNs) and functional network connectivity (FNC) analysis) were carried out on resting-state fMRI data acquired from the 30 participants including 14 healthy controls(HC) and 16 partial epilepsy patients. According to the etiology, all patients are subdivided into temporal lobe epilepsy group (TLE, included 7 patients) and mixed partial epilepsy group (MPE, 9 patients). Using group independent component analysis, eight RSNs were identified, and selected to evaluate functional connectivity and FNC between groups. Compared with the controls, decreased functional connectivity within all RSNs was found in both TLE and MPE. However, dissociating patterns were observed within the 8 RSNs between two patient groups, i.e, compared with TLE, we found decreased functional connectivity in 5 RSNs increased functional connectivity in 1 RSN, and no difference in the other 2 RSNs in MPE. Furthermore, the hierarchical disconnections of FNC was found in two patient groups, in which the intra-system connections were preserved for all three subsystems while the lost connections were confined to intersystem connections in patients with partial epilepsy. These findings may suggest that decreased resting state functional connectivity and disconnection of FNC are two remarkable characteristics of partial epilepsy. The selective impairment of FNC implicated that it is unsuitable to understand the partial epilepsy only from global or local perspective. We presumed that studying epilepsy in the multi-perspective based on RSNs may be a valuable means to assess the functional changes corresponding to specific RSN and may contribute to the understanding of the neuro-pathophysiological mechanism of epilepsy. Public Library of Science 2012-01-05 /pmc/articles/PMC3252302/ /pubmed/22242146 http://dx.doi.org/10.1371/journal.pone.0028196 Text en Luo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Luo, Cheng Qiu, Chuan Guo, Zhiwei Fang, Jiajia Li, Qifu Lei, Xu Xia, Yang Lai, Yongxiu Gong, Qiyong Zhou, Dong Yao, Dezhong
spellingShingle	Luo, Cheng Qiu, Chuan Guo, Zhiwei Fang, Jiajia Li, Qifu Lei, Xu Xia, Yang Lai, Yongxiu Gong, Qiyong Zhou, Dong Yao, Dezhong Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study
author_facet	Luo, Cheng Qiu, Chuan Guo, Zhiwei Fang, Jiajia Li, Qifu Lei, Xu Xia, Yang Lai, Yongxiu Gong, Qiyong Zhou, Dong Yao, Dezhong
author_sort	Luo, Cheng
title	Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study
title_short	Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study
title_full	Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study
title_fullStr	Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study
title_full_unstemmed	Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study
title_sort	disrupted functional brain connectivity in partial epilepsy: a resting-state fmri study
description	Examining the spontaneous activity to understand the neural mechanism of brain disorder is a focus in recent resting-state fMRI. In the current study, to investigate the alteration of brain functional connectivity in partial epilepsy in a systematical way, two levels of analyses (functional connectivity analysis within resting state networks (RSNs) and functional network connectivity (FNC) analysis) were carried out on resting-state fMRI data acquired from the 30 participants including 14 healthy controls(HC) and 16 partial epilepsy patients. According to the etiology, all patients are subdivided into temporal lobe epilepsy group (TLE, included 7 patients) and mixed partial epilepsy group (MPE, 9 patients). Using group independent component analysis, eight RSNs were identified, and selected to evaluate functional connectivity and FNC between groups. Compared with the controls, decreased functional connectivity within all RSNs was found in both TLE and MPE. However, dissociating patterns were observed within the 8 RSNs between two patient groups, i.e, compared with TLE, we found decreased functional connectivity in 5 RSNs increased functional connectivity in 1 RSN, and no difference in the other 2 RSNs in MPE. Furthermore, the hierarchical disconnections of FNC was found in two patient groups, in which the intra-system connections were preserved for all three subsystems while the lost connections were confined to intersystem connections in patients with partial epilepsy. These findings may suggest that decreased resting state functional connectivity and disconnection of FNC are two remarkable characteristics of partial epilepsy. The selective impairment of FNC implicated that it is unsuitable to understand the partial epilepsy only from global or local perspective. We presumed that studying epilepsy in the multi-perspective based on RSNs may be a valuable means to assess the functional changes corresponding to specific RSN and may contribute to the understanding of the neuro-pathophysiological mechanism of epilepsy.
publisher	Public Library of Science
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252302/
_version_	1611498329765576704

Disrupted Functional Brain Connectivity in Partial Epilepsy: A Resting-State fMRI Study

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