Clinical practice: The bleeding child. Part I: primary hemostatic disorders

Mucocutaneous bleeding is common in childhood and may be the result of primary hemostatic disorders such as vascular abnormalities, von Willebrand disease, thrombocytopenia, and platelet dysfunction. A detailed bleeding history and physical examination are essential to distinguish between normal and...

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Main Authors:	van Ommen, C. Heleen, Peters, Marjolein
Format:	Online
Language:	English
Published:	Springer-Verlag 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249149/

id	pubmed-3249149
recordtype	oai_dc
spelling	pubmed-32491492012-01-11 Clinical practice: The bleeding child. Part I: primary hemostatic disorders van Ommen, C. Heleen Peters, Marjolein Review Mucocutaneous bleeding is common in childhood and may be the result of primary hemostatic disorders such as vascular abnormalities, von Willebrand disease, thrombocytopenia, and platelet dysfunction. A detailed bleeding history and physical examination are essential to distinguish between normal and abnormal bleeding and to decide whether it is necessary to perform further laboratory evaluation. Initial laboratory tests include complete blood count, peripheral blood smear, mean platelet volume, von Willebrand factor (VWF) antigen assay, VWF ristocetin cofactor activity, and factor VIII activity. Once thrombocytopenia and von Willebrand disease have been excluded, platelet function should be tested by platelet aggregation. Additional specific diagnostic tests, such as platelet secretion tests and flow cytometry for the detection of platelet surface glycoprotein expression, are needed to confirm the raised hypothesis. Springer-Verlag 2011-07-29 2012-01 /pmc/articles/PMC3249149/ /pubmed/21800040 http://dx.doi.org/10.1007/s00431-011-1532-4 Text en © The Author(s) 2011
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	van Ommen, C. Heleen Peters, Marjolein
spellingShingle	van Ommen, C. Heleen Peters, Marjolein Clinical practice: The bleeding child. Part I: primary hemostatic disorders
author_facet	van Ommen, C. Heleen Peters, Marjolein
author_sort	van Ommen, C. Heleen
title	Clinical practice: The bleeding child. Part I: primary hemostatic disorders
title_short	Clinical practice: The bleeding child. Part I: primary hemostatic disorders
title_full	Clinical practice: The bleeding child. Part I: primary hemostatic disorders
title_fullStr	Clinical practice: The bleeding child. Part I: primary hemostatic disorders
title_full_unstemmed	Clinical practice: The bleeding child. Part I: primary hemostatic disorders
title_sort	clinical practice: the bleeding child. part i: primary hemostatic disorders
description	Mucocutaneous bleeding is common in childhood and may be the result of primary hemostatic disorders such as vascular abnormalities, von Willebrand disease, thrombocytopenia, and platelet dysfunction. A detailed bleeding history and physical examination are essential to distinguish between normal and abnormal bleeding and to decide whether it is necessary to perform further laboratory evaluation. Initial laboratory tests include complete blood count, peripheral blood smear, mean platelet volume, von Willebrand factor (VWF) antigen assay, VWF ristocetin cofactor activity, and factor VIII activity. Once thrombocytopenia and von Willebrand disease have been excluded, platelet function should be tested by platelet aggregation. Additional specific diagnostic tests, such as platelet secretion tests and flow cytometry for the detection of platelet surface glycoprotein expression, are needed to confirm the raised hypothesis.
publisher	Springer-Verlag
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249149/
_version_	1611497514836426752

Clinical practice: The bleeding child. Part I: primary hemostatic disorders

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