Using Multiple Microenvironments to Find Similar Ligand-Binding Sites: Application to Kinase Inhibitor Binding
The recognition of cryptic small-molecular binding sites in protein structures is important for understanding off-target side effects and for recognizing potential new indications for existing drugs. Current methods focus on the geometry and detailed chemical interactions within putative binding poc...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248393/ |