The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer
The Hedgehog (HH) signaling pathway leads to activation of GLI, which transcriptionally regulate target genes. Regulated HH signaling activity is critical during embryogenesis while aberrantly activated HH signaling is evident in a variety of human cancers. Canonical HH signaling engages the transme...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248207/ |